On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase

The specificity of DNMT1 for hemimethylated DNA is a central feature for the inheritance of DNA methylation. We investigated this property in competitive methylation kinetics using hemimethylated (HM), hemihydroxymethylated (OH) and unmethylated (UM) substrates with single CpG sites in a randomized...

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Detalles Bibliográficos
Autores principales: Adam, Sabrina, Klingel, Viviane, Radde, Nicole E, Bashtrykov, Pavel, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359454/
https://www.ncbi.nlm.nih.gov/pubmed/37246710
http://dx.doi.org/10.1093/nar/gkad465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359454/
https://www.ncbi.nlm.nih.gov/pubmed/37246710
http://dx.doi.org/10.1093/nar/gkad465

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