Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNA

Telomere maintenance is a hallmark of malignant cells and allows cancers to divide indefinitely. In some cancers, this is achieved through the alternative lengthening of telomeres (ALT) pathway. Whilst loss of ATRX is a near universal feature of ALT-cancers, it is insufficient in isolation. As such,...

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Detalles Bibliográficos
Autores principales: Rose, Anna M, Goncalves, Tomas, Cunniffe, Siobhan, Geiller, Helene E B, Kent, Thomas, Shepherd, Sam, Ratnaweera, Malitha, O’Sullivan, Roderick J, Gibbons, Richard J, Clynes, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359465/
https://www.ncbi.nlm.nih.gov/pubmed/36940725
http://dx.doi.org/10.1093/nar/gkad150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359465/
https://www.ncbi.nlm.nih.gov/pubmed/36940725
http://dx.doi.org/10.1093/nar/gkad150

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