Investigation of preclinical pharmacokinetics of N-demethylsinomenine, a potential novel analgesic candidate, using an UPLC-MS/MS quantification method

N- Demethylsinomenine (NDSM), the in vivo demethylated metabolite of sinomenine, has exhibited antinociceptive efficacy against various pain models and may become a novel drug candidate for pain management. However, no reported analytical method for quantification of N- Demethylsinomenine in a biolo...

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Detalles Bibliográficos
Autores principales: Yu, Lulu, Qian, Xunjia, Feng, Yiheng, Yin, Yujian, Zhang, Xiao-Dan, Wei, Qianqian, Wang, Liyun, Rong, Weiwei, Li, Jie-Jia, Li, Jun-Xu, Zhu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359479/
https://www.ncbi.nlm.nih.gov/pubmed/37483270
http://dx.doi.org/10.3389/fchem.2023.1222560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359479/
https://www.ncbi.nlm.nih.gov/pubmed/37483270
http://dx.doi.org/10.3389/fchem.2023.1222560

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