IL-17A-producing CD8(+) T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts

OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic stroma composed of cancer-associated fibroblasts (CAF) and interspersed immune cells. A non-canonical CD8(+) T-cell subpopulation producing IL-17A (Tc17) promotes autoimmunity and has been identified in t...

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Detalles Bibliográficos
Autores principales: Picard, Felix Simon Ruben, Lutz, Veronika, Brichkina, Anna, Neuhaus, Felix, Ruckenbrod, Teresa, Hupfer, Anna, Raifer, Hartmann, Klein, Matthias, Bopp, Tobias, Pfefferle, Petra Ina, Savai, Rajkumar, Prinz, Immo, Waisman, Ari, Moos, Sonja, Chang, Hyun-Dong, Heinrich, Stefan, Bartsch, Detlef K, Buchholz, Malte, Singh, Shiv, Tu, Mengyu, Klein, Lukas, Bauer, Christian, Liefke, Robert, Burchert, Andreas, Chung, Ho-Ryun, Mayer, Philipp, Gress, Thomas M, Lauth, Matthias, Gaida, Matthias, Huber, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Pancreas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359545/
https://www.ncbi.nlm.nih.gov/pubmed/36759154
http://dx.doi.org/10.1136/gutjnl-2022-327855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359545/
https://www.ncbi.nlm.nih.gov/pubmed/36759154
http://dx.doi.org/10.1136/gutjnl-2022-327855

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