RIPK3–MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis

BACKGROUNDS: The stimulator of interferon genes (STING) is an important driver in various inflammatory diseases. METHODS AND RESULTS: Here, we have demonstrated that inhibition of RIPK3 and MLKL dampens STING signaling, indicating that necroptosis may be involved in sustaining STING signaling. Furth...

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Detalles Bibliográficos
Autores principales: Zhang, Xufei, Wu, Jie, Liu, Qinjie, Li, Xuanheng, Yang, Yiyu, Wu, Lei, Wu, Xiuwen, Zhao, Yun, Ren, Jianan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359592/
https://www.ncbi.nlm.nih.gov/pubmed/37475188
http://dx.doi.org/10.1002/ctm2.1334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359592/
https://www.ncbi.nlm.nih.gov/pubmed/37475188
http://dx.doi.org/10.1002/ctm2.1334

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