Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site

SAMHD1 dNTP hydrolase activity places it at the crossroad of several important biological pathways, such as viral restriction, cell cycle regulation, and innate immunity. Recently, a dNTPase independent function for SAMHD1 in homologous recombination (HR) of DNA double-strand breaks has been identif...

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Detalles Bibliográficos
Autores principales: Simermeyer, Theresa L, Batalis, Stephanie, Rogers, LeAnn C, Zalesak, Owen J, Hollis, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359594/
https://www.ncbi.nlm.nih.gov/pubmed/37246644
http://dx.doi.org/10.1093/nar/gkad447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359594/
https://www.ncbi.nlm.nih.gov/pubmed/37246644
http://dx.doi.org/10.1093/nar/gkad447

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