High fidelity DNA strand-separation is the major specificity determinant in DNA methyltransferase CcrM’s catalytic mechanism

Strand-separation is emerging as a novel DNA recognition mechanism but the underlying mechanisms and quantitative contribution of strand-separation to fidelity remain obscure. The bacterial DNA adenine methyltransferase, CcrM, recognizes 5′GANTC′3 sequences through a DNA strand-separation mechanism...

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Detalles Bibliográficos
Autores principales: Konttinen, Olivia, Carmody, Jason, Kurnik, Martin, Johnson, Kenneth A, Reich, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359602/
https://www.ncbi.nlm.nih.gov/pubmed/37326016
http://dx.doi.org/10.1093/nar/gkad443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359602/
https://www.ncbi.nlm.nih.gov/pubmed/37326016
http://dx.doi.org/10.1093/nar/gkad443

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