The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells

Telomeres are the nucleoprotein structures at the ends of linear chromosomes. Telomeres are transcribed into long non-coding Telomeric Repeat-Containing RNA (TERRA), whose functions rely on its ability to associate with telomeric chromatin. The conserved THO complex (THOC) was previously identified...

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Detalles Bibliográficos
Autores principales: Fernandes, Rita Valador, Lingner, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359610/
https://www.ncbi.nlm.nih.gov/pubmed/37246640
http://dx.doi.org/10.1093/nar/gkad448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359610/
https://www.ncbi.nlm.nih.gov/pubmed/37246640
http://dx.doi.org/10.1093/nar/gkad448

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