Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics

Many types of damage, including abasic sites, block replicative DNA polymerases causing replication fork uncoupling and generating ssDNA. AP-Endonuclease 1 (APE1) has been shown to cleave abasic sites in ssDNA. Importantly, APE1 cleavage of ssDNA at a replication fork has significant biological impl...

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Detalles Bibliográficos
Autores principales: Hoitsma, Nicole M, Norris, Jessica, Khoang, Thu H, Kaushik, Vikas, Chadda, Rahul, Antony, Edwin, Hedglin, Mark, Freudenthal, Bret D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359615/
https://www.ncbi.nlm.nih.gov/pubmed/37264933
http://dx.doi.org/10.1093/nar/gkad481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359615/
https://www.ncbi.nlm.nih.gov/pubmed/37264933
http://dx.doi.org/10.1093/nar/gkad481

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