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Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics
Many types of damage, including abasic sites, block replicative DNA polymerases causing replication fork uncoupling and generating ssDNA. AP-Endonuclease 1 (APE1) has been shown to cleave abasic sites in ssDNA. Importantly, APE1 cleavage of ssDNA at a replication fork has significant biological impl...
Autores principales: | Hoitsma, Nicole M, Norris, Jessica, Khoang, Thu H, Kaushik, Vikas, Chadda, Rahul, Antony, Edwin, Hedglin, Mark, Freudenthal, Bret D |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359615/ https://www.ncbi.nlm.nih.gov/pubmed/37264933 http://dx.doi.org/10.1093/nar/gkad481 |
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