IFI16 phase separation via multi-phosphorylation drives innate immune signaling

The interferon inducible protein 16 (IFI16) is a prominent sensor of nuclear pathogenic DNA, initiating innate immune signaling and suppressing viral transcription. However, little is known about mechanisms that initiate IFI16 antiviral functions or its regulation within the host DNA-filled nucleus....

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Detalles Bibliográficos
Autores principales: Liu, Dawei, Lum, Krystal K, Treen, Nicholas, Núñez, Corazón T, Yang, Jinhang, Howard, Timothy R, Levine, Michael, Cristea, Ileana M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359621/
https://www.ncbi.nlm.nih.gov/pubmed/37283074
http://dx.doi.org/10.1093/nar/gkad449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359621/
https://www.ncbi.nlm.nih.gov/pubmed/37283074
http://dx.doi.org/10.1093/nar/gkad449

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