Prolonging genetic circuit stability through adaptive evolution of overlapping genes

The development of synthetic biological circuits that maintain functionality over application-relevant time scales remains a significant challenge. Here, we employed synthetic overlapping sequences in which one gene is encoded or ‘entangled’ entirely within an alternative reading frame of another ge...

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Detalles Bibliográficos
Autores principales: Chlebek, Jennifer L, Leonard, Sean P, Kang-Yun, Christina, Yung, Mimi C, Ricci, Dante P, Jiao, Yongqin, Park, Dan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359631/
https://www.ncbi.nlm.nih.gov/pubmed/37260076
http://dx.doi.org/10.1093/nar/gkad484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359631/
https://www.ncbi.nlm.nih.gov/pubmed/37260076
http://dx.doi.org/10.1093/nar/gkad484

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