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Cas1–Cas2 physically and functionally interacts with DnaK to modulate CRISPR Adaptation
Prokaryotic Cas1–Cas2 protein complexes generate adaptive immunity to mobile genetic elements (MGEs), by capture and integration of MGE DNA in to CRISPR sites. De novo immunity relies on naive adaptation—Cas1–Cas2 targeting of MGE DNA without the aid of pre-existing immunity ‘interference’ complexes...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359635/ https://www.ncbi.nlm.nih.gov/pubmed/37264902 http://dx.doi.org/10.1093/nar/gkad473 |