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Cas1–Cas2 physically and functionally interacts with DnaK to modulate CRISPR Adaptation

Prokaryotic Cas1–Cas2 protein complexes generate adaptive immunity to mobile genetic elements (MGEs), by capture and integration of MGE DNA in to CRISPR sites. De novo immunity relies on naive adaptation—Cas1–Cas2 targeting of MGE DNA without the aid of pre-existing immunity ‘interference’ complexes...

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Detalles Bibliográficos
Autores principales:	Killelea, Tom, Dimude, Juachi U, He, Liu, Stewart, Alison L, Kemm, Fiona E, Radovčić, Marin, Ivančić-Baće, Ivana, Rudolph, Christian J, Bolt, Edward L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359635/ https://www.ncbi.nlm.nih.gov/pubmed/37264902 http://dx.doi.org/10.1093/nar/gkad473

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