Phosphorylation status of MUS81 is a modifier of Olaparib sensitivity in BRCA2-deficient cells

The MUS81 complex is crucial for preserving genome stability through resolution of branched DNA intermediates in mitosis and also for the processing of deprotected replication forks in BRCA2-deficient cells. Because of the existence of two different MUS81 complexes in mammalian cells that act in M-...

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Detalles Bibliográficos
Autores principales: Blandino, Francesca, Malacaria, Eva, Figlioli, Carolina, Noto, Alessandro, Pugliese, Giusj Monia, Franchitto, Annapaola, Pichierri, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359636/
https://www.ncbi.nlm.nih.gov/pubmed/37254810
http://dx.doi.org/10.1093/nar/gkad470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359636/
https://www.ncbi.nlm.nih.gov/pubmed/37254810
http://dx.doi.org/10.1093/nar/gkad470

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