KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway

OBJECTIVE: Somatic KRAS mutations have been identified in the majority of brain arteriovenous malformations (bAVMs), and subsequent in vivo experiments have confirmed that KRAS mutation in endothelial cells (ECs) causes AVMs in mouse and zebrafish models. Our previous study demonstrated that the KRA...

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Detalles Bibliográficos
Autores principales: Xu, Hongyuan, Huo, Ran, Li, Hao, Jiao, Yuming, Weng, Jiancong, Wang, Jie, Yan, Zihan, Zhang, Junze, Zhao, Shaozhi, He, Qiheng, Sun, Yingfan, Wang, Shuo, Cao, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359780/
https://www.ncbi.nlm.nih.gov/pubmed/36418055
http://dx.doi.org/10.1136/svn-2022-001700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359780/
https://www.ncbi.nlm.nih.gov/pubmed/36418055
http://dx.doi.org/10.1136/svn-2022-001700

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