Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells

Designing a targeted screening library of bioactive small molecules is a challenging task since most compounds modulate their effects through multiple protein targets with varying degrees of potency and selectivity. We implemented analytic procedures for designing anticancer compound libraries adjus...

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Detalles Bibliográficos
Autores principales: Athanasiadis, Paschalis, Ravikumar, Balaguru, Elliott, Richard J.R., Dawson, John C., Carragher, Neil O., Clemons, Paul A., Johanssen, Timothy, Ebner, Daniel, Aittokallio, Tero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359939/
https://www.ncbi.nlm.nih.gov/pubmed/37485377
http://dx.doi.org/10.1016/j.isci.2023.107209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359939/
https://www.ncbi.nlm.nih.gov/pubmed/37485377
http://dx.doi.org/10.1016/j.isci.2023.107209

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