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Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells
Designing a targeted screening library of bioactive small molecules is a challenging task since most compounds modulate their effects through multiple protein targets with varying degrees of potency and selectivity. We implemented analytic procedures for designing anticancer compound libraries adjus...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359939/ https://www.ncbi.nlm.nih.gov/pubmed/37485377 http://dx.doi.org/10.1016/j.isci.2023.107209 |