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Rapamycin treatment induces tubular proteinuria: role of megalin-mediated protein reabsorption

Introduction: Rapamycin is an immunosuppressor that acts by inhibiting the serine/threonine kinase mechanistic target of rapamycin complex 1. Therapeutic use of rapamycin is limited by its adverse effects. Proteinuria is an important marker of kidney damage and a risk factor for kidney diseases prog...

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Detalles Bibliográficos
Autores principales:	Peres, Rodrigo A. S., Peruchetti, Diogo B., Silva-Aguiar, Rodrigo P., Teixeira, Douglas E., Gomes, Carlos P., Takiya, Christina M., Pinheiro, Ana Acacia S., Caruso-Neves, Celso
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359992/ https://www.ncbi.nlm.nih.gov/pubmed/37484026 http://dx.doi.org/10.3389/fphar.2023.1194816

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