Development of a Novel [(11)C]CO-Labeled Positron Emission Tomography Radioligand [(11)C]BIO-1819578 for the Detection of O-GlcNAcase Enzyme Activity

[Image: see text] Imaging O-GlcNAcase OGA by positron emission tomography (PET) could provide information on the pathophysiological pathway of neurodegenerative diseases and important information on drug-target engagement and be helpful in dose selection of therapeutic drugs. Our aim was to develop...

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Detalles Bibliográficos
Autores principales: Nag, Sangram, Bolin, Martin, Datta, Prodip, Arakawa, Ryosuke, Forsberg Morén, Anton, Khani Maynaq, Yasir, Lin, Edward, Genung, Nathan, Hering, Heike, Guckian, Kevin, Martarello, Laurent, Kaliszczak, Maciej, Halldin, Christer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360070/
https://www.ncbi.nlm.nih.gov/pubmed/37377046
http://dx.doi.org/10.1021/acschemneuro.3c00247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360070/
https://www.ncbi.nlm.nih.gov/pubmed/37377046
http://dx.doi.org/10.1021/acschemneuro.3c00247

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