SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy

BACKGROUND: SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch repair (MMR) in neoplastic cells. However, it remains unclear whether SETD2 dysfunction is a complementary or independent factor to microsatellite instability-high (MSI-H) and...

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Detalles Bibliográficos
Autores principales: Zheng, Xiaobin, Lin, Jing, Xiong, Jiani, Guan, Yanfang, Lan, Bin, Li, Yi, Gao, Xuan, Fei, Zhaodong, Chen, Lisha, Chen, Lizhu, Chen, Ling, Chen, Gang, Guo, Zengqing, Yi, Xin, Cao, Weiguo, Ai, Xinghao, Zhou, Chengzhi, Li, Xiaofeng, Zhao, Jun, Yan, Xiangtao, Yu, Qitao, Si, Lu, Chen, Yu, Chen, Chuanben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360270/
https://www.ncbi.nlm.nih.gov/pubmed/37479966
http://dx.doi.org/10.1186/s12885-023-10920-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360270/
https://www.ncbi.nlm.nih.gov/pubmed/37479966
http://dx.doi.org/10.1186/s12885-023-10920-4

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