Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner

Hydrogen (H(2)) can protect against blood‒brain barrier (BBB) damage in sepsis-associated encephalopathy (SAE), but the mechanism is still unclear. We examined whether it is related to PPARα and its regulatory targets, ABC efflux transporters. After injection with DMSO/GW6471 (a PPARα inhibitor), th...

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Detalles Bibliográficos
Autores principales: Bai, Yuanyuan, Mi, Wen, Meng, Xiaoyin, Dong, Beibei, Jiang, Yi, Lu, Yuechun, Yu, Yonghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360271/
https://www.ncbi.nlm.nih.gov/pubmed/37474902
http://dx.doi.org/10.1186/s12868-023-00795-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360271/
https://www.ncbi.nlm.nih.gov/pubmed/37474902
http://dx.doi.org/10.1186/s12868-023-00795-3

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