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Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner

Hydrogen (H(2)) can protect against blood‒brain barrier (BBB) damage in sepsis-associated encephalopathy (SAE), but the mechanism is still unclear. We examined whether it is related to PPARα and its regulatory targets, ABC efflux transporters. After injection with DMSO/GW6471 (a PPARα inhibitor), th...

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Detalles Bibliográficos
Autores principales:	Bai, Yuanyuan, Mi, Wen, Meng, Xiaoyin, Dong, Beibei, Jiang, Yi, Lu, Yuechun, Yu, Yonghao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360271/ https://www.ncbi.nlm.nih.gov/pubmed/37474902 http://dx.doi.org/10.1186/s12868-023-00795-3

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