Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT

The recognition that cytosolic mitochondrial DNA (mtDNA) activates cyclic GMP–AMP synthase-stimulator of interferon genes (cGAS-STING) innate immune signaling has unlocked novel disease mechanisms. Here, an uncharacterized variant predicted to affect TOP1MT function, P193L, was discovered in a famil...

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Detalles Bibliográficos
Autores principales: Al Khatib, Iman, Deng, Jingti, Lei, Yuanjiu, Torres-Odio, Sylvia, Rojas, Gladys R, Newman, Laura E, Chung, Brian K, Symes, Andrew, Zhang, Hongliang, Huang, Shar-yin N, Pommier, Yves, Khan, Aneal, Shadel, Gerald S, West, Andrew Phillip, Gibson, William T, Shutt, Timothy E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360396/
https://www.ncbi.nlm.nih.gov/pubmed/37129502
http://dx.doi.org/10.1093/hmg/ddad062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360396/
https://www.ncbi.nlm.nih.gov/pubmed/37129502
http://dx.doi.org/10.1093/hmg/ddad062

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