Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates

BACKGROUND: Infants undergoing cardiac surgery with cardiopulmonary bypass (CPB) frequently receive intraoperative methylprednisolone (MP) to suppress CPB-related inflammation; however, the optimal dosing strategy and efficacy of MP remain unclear. METHODS: We retrospectively analyzed all infants un...

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Detalles Bibliográficos
Autores principales: Foote, Henry P., Wu, Huali, Balevic, Stephen J., Thompson, Elizabeth J., Hill, Kevin D., Graham, Eric M., Hornik, Christoph P., Kumar, Karan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361697/
https://www.ncbi.nlm.nih.gov/pubmed/37484782
http://dx.doi.org/10.32604/chd.2023.026262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361697/
https://www.ncbi.nlm.nih.gov/pubmed/37484782
http://dx.doi.org/10.32604/chd.2023.026262

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