Cargando…

Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates

BACKGROUND: Infants undergoing cardiac surgery with cardiopulmonary bypass (CPB) frequently receive intraoperative methylprednisolone (MP) to suppress CPB-related inflammation; however, the optimal dosing strategy and efficacy of MP remain unclear. METHODS: We retrospectively analyzed all infants un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Foote, Henry P., Wu, Huali, Balevic, Stephen J., Thompson, Elizabeth J., Hill, Kevin D., Graham, Eric M., Hornik, Christoph P., Kumar, Karan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361697/ https://www.ncbi.nlm.nih.gov/pubmed/37484782 http://dx.doi.org/10.32604/chd.2023.026262

Ejemplares similares

Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass
por: Hornik, Christoph P., et al.
Publicado: (2019)

A point-of-care pharmacokinetic/pharmacodynamic trial in critically ill children: Study design and feasibility
por: Thompson, Elizabeth J., et al.
Publicado: (2023)

A comparison of three dose timings of methylprednisolone in infant cardiopulmonary bypass
por: Withington, Davinia E, et al.
Publicado: (2014)

Methylprednisolone Plasma Concentrations During Cardiac Surgery With Cardiopulmonary Bypass in Pediatric Patients
por: van Saet, Annewil, et al.
Publicado: (2021)

Effects of high-dose methylprednisolone on neonatal pulmonary function after cardiopulmonary bypass and deep hypothermic circulatory arrest
por: Abdul-Khaliq, H, et al.
Publicado: (2001)

Coagulation and neonatal bypass: an assessment of changes in coagulation factor concentration during cardiopulmonary bypass in neonates, with modified ultrafiltration
por: Arnold, P, et al.
Publicado: (1999)

Pharmacokinetics of hydroxychloroquine in paediatric lupus: data from a novel, direct-to-family clinical trial
por: Balevic, Stephen J, et al.
Publicado: (2022)

Pharmacokinetics of Oral Vitamin D in Children with Obesity and Asthma
por: Lang, Jason E., et al.
Publicado: (2023)

Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass
por: Mian, P., et al.
Publicado: (2019)

Hydroxychloroquine PK and exposure-response in pregnancies with lupus: the importance of adherence for neonatal outcomes
por: Balevic, Stephen J, et al.
Publicado: (2022)

External Evaluation of Risperidone Population Pharmacokinetic Models Using Opportunistic Pediatric Data
por: Karatza, Eleni, et al.
Publicado: (2022)

Myocardial histology and outcome after cardiopulmonary bypass of neonatal piglets
por: Tirilomis, Theodor, et al.
Publicado: (2015)

Myocardial contractile function in survived neonatal piglets after cardiopulmonary bypass
por: Tirilomis, Theodor, et al.
Publicado: (2010)

Estimation of Body Fat Percentage for Clinical Pharmacokinetic Studies in Children
por: Green, Thomas P., et al.
Publicado: (2020)

Cardiopulmonary Bypass
por: Rondelez, Luc, et al.
Publicado: (2010)

Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine
por: Padawer-Curry, Jonah A., et al.
Publicado: (2021)

Perspective on Cerebral Autoregulation Monitoring in Neonatal Cardiac Surgery Requiring Cardiopulmonary Bypass
por: Spilka, Jared M., et al.
Publicado: (2021)

Effects of Cardiopulmonary Bypass on Propofol Pharmacokinetics and Bispectral Index During Coronary Surgery
por: Barbosa, Ricardo Antonio G., et al.
Publicado: (2009)

Pharmacokinetic model of unfractionated heparin during and after cardiopulmonary bypass in cardiac surgery
por: Jia, Zaishen, et al.
Publicado: (2015)

Cefazolin Pharmacokinetics in Premature Infants
por: Balevic, Stephen J., et al.
Publicado: (2019)

Cardiopulmonary bypass in neonates and infants: advantages of high flow high hematocrit bypass strategy—clinical practice review
por: Ramakrishnan, Karthik, et al.
Publicado: (2023)

Bringing research directly to families in the era of COVID-19
por: Balevic, Stephen J., et al.
Publicado: (2020)

Basics of cardiopulmonary bypass
por: Sarkar, Manjula, et al.
Publicado: (2017)

Fibrinolysis during cardiopulmonary bypass detected with thromboelastography
por: Hájek, R, et al.
Publicado: (2007)

Factors associated with hyperglycemia and low insulin levels in children undergoing cardiac surgery with cardiopulmonary bypass who received a single high dose of methylprednisolone
por: Arkader, Ronaldo, et al.
Publicado: (2013)

Cardiopulmonary resuscitation with cardiopulmonary bypass after cardiac surgery
por: Rodrigus, I, et al.
Publicado: (2000)

The Response of Hemostatic Marker Levels to Activated Factor VII in a Neonate following Cardiopulmonary Bypass
por: Eisses, Michael J., et al.
Publicado: (2009)

Sex steroids in cardiopulmonary bypass
por: Trotter, Andreas, et al.
Publicado: (1997)

Weaning from cardiopulmonary bypass
por: Kim, Heezoo
Publicado: (2013)

Cardiopulmonary Bypass and Oxidative Stress
por: Zakkar, Mustafa, et al.
Publicado: (2015)

Pulmonary complications of cardiopulmonary bypass
por: Huffmyer, Julie L., et al.
Publicado: (2015)

Cardiopulmonary Bypass Priming Using Autologous Cord Blood in Neonatal Congenital Cardiac Surgery
por: Choi, Eun Seok, et al.
Publicado: (2016)

Cardiopulmonary Bypass Video Is an Effective Learning Tool
por: Tseng, Michael T., et al.
Publicado: (2020)

Delivering clinical trials at home: protocol, design and implementation of a direct-to-family paediatric lupus trial
por: Randell, Rachel L, et al.
Publicado: (2021)

Predictive value of rotational thromboelastometry during cardiopulmonary bypass for thrombocytopenia and hypofibrinogenemia after weaning of cardiopulmonary bypass
por: Ji, Sung-Mi, et al.
Publicado: (2015)

Functional Performance of Different Venous Limb Options in Simulated Neonatal/Pediatric Cardiopulmonary Bypass Circuits
por: Caneo, Luiz Fernando, et al.
Publicado: (2018)

microRNA Expression Levels Change in Neonatal Patients During and After Exposure to Cardiopulmonary Bypass
por: Hsieh, Lance, et al.
Publicado: (2022)

Application of a pharmacokinetics-pharmacodynamics approach to the free propofol plasma levels during coronary artery bypass grafting surgery with hypothermic cardiopulmonary bypass
por: Silva-Filho, Carlos R., et al.
Publicado: (2018)

Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications
por: Ferradal, Silvina L., et al.
Publicado: (2017)

Pharmacokinetics after Periocular Methylprednisolone Sodium Succinate Injection in Rabbit Eyes
por: Lu, Hua-Yi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hrqs11hds7ee7cbv8a011j484p