Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase

The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically non-permissive state. The transition between inactive and active conformation...

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Detalles Bibliográficos
Autores principales: Koudelková, Lenka, Pelantová, Markéta, Brůhová, Zuzana, Sztacho, Martin, Pavlík, Vojtěch, Pánek, Dalibor, Gemperle, Jakub, Talacko, Pavel, Brábek, Jan, Rösel, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361714/
https://www.ncbi.nlm.nih.gov/pubmed/37428018
http://dx.doi.org/10.7554/eLife.82428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361714/
https://www.ncbi.nlm.nih.gov/pubmed/37428018
http://dx.doi.org/10.7554/eLife.82428

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