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Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically non-permissive state. The transition between inactive and active conformation...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361714/ https://www.ncbi.nlm.nih.gov/pubmed/37428018 http://dx.doi.org/10.7554/eLife.82428 |