Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. Stromal fibroblasts are a dominant but heterogenous population within the tumor microenvironment and therapeutic targeting of stromal subsets may have therapeutic utility. Here, we combine spa...

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Detalles Bibliográficos
Autores principales: Croft, Wayne, Pearce, Hayden, Margielewska-Davies, Sandra, Lim, Lindsay, Nicol, Samantha M, Zayou, Fouzia, Blakeway, Daniel, Marcon, Francesca, Powell-Brett, Sarah, Mahon, Brinder, Merard, Reena, Zuo, Jianmin, Middleton, Gary, Roberts, Keith, Brown, Rachel M, Moss, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361717/
https://www.ncbi.nlm.nih.gov/pubmed/37350578
http://dx.doi.org/10.7554/eLife.86125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361717/
https://www.ncbi.nlm.nih.gov/pubmed/37350578
http://dx.doi.org/10.7554/eLife.86125

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