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Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models

A product of the immediate early gene Arc (Activity-regulated cytoskeleton-associated protein or Arc protein) of retroviral ancestry resides in the genome of all tetrapods for millions of years and is expressed endogenously in neurons. It is a well-known protein, very important for synaptic plastici...

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Autores principales: Sibarov, Dmitry A., Tsytsarev, Vassiliy, Volnova, Anna, Vaganova, Anastasia N., Alves, Janaina, Rojas, Legier, Sanabria, Priscila, Ignashchenkova, Alla, Savage, Elton D., Inyushin, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361770/
https://www.ncbi.nlm.nih.gov/pubmed/37483450
http://dx.doi.org/10.3389/fneur.2023.1201104
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author Sibarov, Dmitry A.
Tsytsarev, Vassiliy
Volnova, Anna
Vaganova, Anastasia N.
Alves, Janaina
Rojas, Legier
Sanabria, Priscila
Ignashchenkova, Alla
Savage, Elton D.
Inyushin, Mikhail
author_facet Sibarov, Dmitry A.
Tsytsarev, Vassiliy
Volnova, Anna
Vaganova, Anastasia N.
Alves, Janaina
Rojas, Legier
Sanabria, Priscila
Ignashchenkova, Alla
Savage, Elton D.
Inyushin, Mikhail
author_sort Sibarov, Dmitry A.
collection PubMed
description A product of the immediate early gene Arc (Activity-regulated cytoskeleton-associated protein or Arc protein) of retroviral ancestry resides in the genome of all tetrapods for millions of years and is expressed endogenously in neurons. It is a well-known protein, very important for synaptic plasticity and memory consolidation. Activity-dependent Arc expression concentrated in glutamatergic synapses affects the long-time synaptic strength of those excitatory synapses. Because it modulates excitatory-inhibitory balance in a neuronal network, the Arc gene itself was found to be related to the pathogenesis of epilepsy. General Arc knockout rodent models develop a susceptibility to epileptic seizures. Because of activity dependence, synaptic Arc protein synthesis also is affected by seizures. Interestingly, it was found that Arc protein in synapses of active neurons self-assemble in capsids of retrovirus-like particles, which can transfer genetic information between neurons, at least across neuronal synaptic boutons. Released Arc particles can be accumulated in astrocytes after seizures. It is still not known how capsid assembling and transmission timescale is affected by seizures. This scientific field is relatively novel and is experiencing swift transformation as it grapples with difficult concepts in light of evolving experimental findings. We summarize the emergent literature on the subject and also discuss the specific rodent models for studying Arc effects in epilepsy. We summarized both to clarify the possible role of Arc-related pseudo-viral particles in epileptic disorders, which may be helpful to researchers interested in this growing area of investigation.
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spelling pubmed-103617702023-07-22 Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models Sibarov, Dmitry A. Tsytsarev, Vassiliy Volnova, Anna Vaganova, Anastasia N. Alves, Janaina Rojas, Legier Sanabria, Priscila Ignashchenkova, Alla Savage, Elton D. Inyushin, Mikhail Front Neurol Neurology A product of the immediate early gene Arc (Activity-regulated cytoskeleton-associated protein or Arc protein) of retroviral ancestry resides in the genome of all tetrapods for millions of years and is expressed endogenously in neurons. It is a well-known protein, very important for synaptic plasticity and memory consolidation. Activity-dependent Arc expression concentrated in glutamatergic synapses affects the long-time synaptic strength of those excitatory synapses. Because it modulates excitatory-inhibitory balance in a neuronal network, the Arc gene itself was found to be related to the pathogenesis of epilepsy. General Arc knockout rodent models develop a susceptibility to epileptic seizures. Because of activity dependence, synaptic Arc protein synthesis also is affected by seizures. Interestingly, it was found that Arc protein in synapses of active neurons self-assemble in capsids of retrovirus-like particles, which can transfer genetic information between neurons, at least across neuronal synaptic boutons. Released Arc particles can be accumulated in astrocytes after seizures. It is still not known how capsid assembling and transmission timescale is affected by seizures. This scientific field is relatively novel and is experiencing swift transformation as it grapples with difficult concepts in light of evolving experimental findings. We summarize the emergent literature on the subject and also discuss the specific rodent models for studying Arc effects in epilepsy. We summarized both to clarify the possible role of Arc-related pseudo-viral particles in epileptic disorders, which may be helpful to researchers interested in this growing area of investigation. Frontiers Media S.A. 2023-07-07 /pmc/articles/PMC10361770/ /pubmed/37483450 http://dx.doi.org/10.3389/fneur.2023.1201104 Text en Copyright © 2023 Sibarov, Tsytsarev, Volnova, Vaganova, Alves, Rojas, Sanabria, Ignashchenkova, Savage and Inyushin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Sibarov, Dmitry A.
Tsytsarev, Vassiliy
Volnova, Anna
Vaganova, Anastasia N.
Alves, Janaina
Rojas, Legier
Sanabria, Priscila
Ignashchenkova, Alla
Savage, Elton D.
Inyushin, Mikhail
Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models
title Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models
title_full Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models
title_fullStr Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models
title_full_unstemmed Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models
title_short Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models
title_sort arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361770/
https://www.ncbi.nlm.nih.gov/pubmed/37483450
http://dx.doi.org/10.3389/fneur.2023.1201104
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