Induction of cancer neoantigens facilitates development of clinically relevant models for the study of pancreatic cancer immunobiology

Neoantigen burden and CD8 T cell infiltrate are associated with clinical outcome in pancreatic ductal adenocarcinoma (PDAC). A shortcoming of many genetic models of PDAC is the lack of neoantigen burden and limited T cell infiltrate. The goal of the present study was to develop clinically relevant m...

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Detalles Bibliográficos
Autores principales: Panni, Usman Y., Chen, Michael Y., Zhang, Felicia, Cullinan, Darren R., Li, Lijin, James, C. Alston, Zhang, Xiuli, Rogers, S., Alarcon, A., Baer, John M., Zhang, Daoxiang, Gao, Feng, Miller, Christopher A., Gong, Qingqing, Lim, Kian-Huat, DeNardo, David G., Goedegebuure, S. Peter, Gillanders, William E., Hawkins, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361914/
https://www.ncbi.nlm.nih.gov/pubmed/37179276
http://dx.doi.org/10.1007/s00262-023-03463-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361914/
https://www.ncbi.nlm.nih.gov/pubmed/37179276
http://dx.doi.org/10.1007/s00262-023-03463-x

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