Association between CYP2B6 genetic variability and cyclophosphamide therapy in pediatric patients with neuroblastoma

Cyclophosphamide, an oxazaphosphorine prodrug is frequently used in treatment of neuroblastoma, which is one of the most prevalent solid organ malignancies in infants and young children. Cytochrome P450 2B6 (CYP2B6) is the major catalyst and CYP2C19 is the minor enzyme in bioactivation and inactivat...

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Detalles Bibliográficos
Autores principales: Mangó, Katalin, Fekete, Ferenc, Kiss, Ádám Ferenc, Erdős, Réka, Fekete, János Tibor, Bűdi, Tamás, Bruckner, Edit, Garami, Miklós, Micsik, Tamás, Monostory, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361978/
https://www.ncbi.nlm.nih.gov/pubmed/37479763
http://dx.doi.org/10.1038/s41598-023-38983-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361978/
https://www.ncbi.nlm.nih.gov/pubmed/37479763
http://dx.doi.org/10.1038/s41598-023-38983-0

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