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Human PNPase causes RNA stabilization and accumulation of R-loops in the Escherichia coli model system
Polyribonucleotide phosphorylase (PNPase) is a phosphorolytic RNA exonuclease highly conserved throughout evolution. In Escherichia coli, PNPase controls complex phenotypic traits like biofilm formation and growth at low temperature. In human cells, PNPase is located in mitochondria, where it is imp...
Autores principales: | Falchi, Federica A., Forti, Francesca, Carnelli, Cristina, Genco, Aurelia, Pizzoccheri, Roberto, Manzari, Caterina, Pavesi, Giulio, Briani, Federica |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362022/ https://www.ncbi.nlm.nih.gov/pubmed/37479726 http://dx.doi.org/10.1038/s41598-023-38924-x |
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