Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics

Postnatal cell fate is postulated to be primarily determined by the local tissue microenvironment. Here, we find that Mediator 1 (Med1) dependent epigenetic mechanisms dictate tissue-specific lineage commitment and progression of dental epithelia. Deletion of Med1, a key component of the Mediator co...

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Detalles Bibliográficos
Autores principales: Thaler, Roman, Yoshizaki, Keigo, Nguyen, Thai, Fukumoto, Satoshi, Den Besten, Pamela, Bikle, Daniel D., Oda, Yuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362024/
https://www.ncbi.nlm.nih.gov/pubmed/37479880
http://dx.doi.org/10.1038/s42003-023-05105-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362024/
https://www.ncbi.nlm.nih.gov/pubmed/37479880
http://dx.doi.org/10.1038/s42003-023-05105-5

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