PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation

The increase of lactate is an independent risk factor for patients with sepsis-induced acute kidney injury (SAKI). However, whether elevated lactate directly promotes SAKI and its mechanism remain unclear. Here we revealed that downregulation of the deacetylase Sirtuin 3 (SIRT3) mediated the hyperac...

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Detalles Bibliográficos
Autores principales: An, Sheng, Yao, Yi, Hu, Hongbin, Wu, Junjie, Li, Jiaxin, Li, Lulan, Wu, Jie, Sun, Maomao, Deng, Zhiya, Zhang, Yaoyuan, Gong, Shenhai, Huang, Qiaobing, Chen, Zhongqing, Zeng, Zhenhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362039/
https://www.ncbi.nlm.nih.gov/pubmed/37479690
http://dx.doi.org/10.1038/s41419-023-05952-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362039/
https://www.ncbi.nlm.nih.gov/pubmed/37479690
http://dx.doi.org/10.1038/s41419-023-05952-4

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