Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment

Inhibition of actin remodeling in nerves modulates action potential propagation and therefore could be used to treat acute pain. N-001 is a novel protein analgesic engineered from several C. Botulinum toxins. N-001 targets sensory neurons through ganglioside GT1b binding and ADP-ribosylates G-actin...

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Detalles Bibliográficos
Autores principales: Allen, Derek, Hanumantharao, Samerender Nagam, McDonell, Rylie, Irvine, Karen-Amanda, Sahbaie, Peyman, Clark, David, Blum, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362049/
https://www.ncbi.nlm.nih.gov/pubmed/37479740
http://dx.doi.org/10.1038/s41598-023-38618-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362049/
https://www.ncbi.nlm.nih.gov/pubmed/37479740
http://dx.doi.org/10.1038/s41598-023-38618-4

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