Potent and selective eradication of tumor cells by an EpCAM-targeted Ras-degrading enzyme

Despite decades of efforts, an urgent need remains to develop tumor cell-selective rat sarcoma (Ras)-targeting therapies that can treat patients with Ras-driven tumors. Here we report modular engineered proteins that degrade Ras selectively in tumor cells that overexpress the tumor cell marker epith...

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Detalles Bibliográficos
Autores principales: Palacio-Castañeda, Valentina, van de Crommert, Bas, Verploegen, Elke, Overeem, Mike, van Oostrum, Jenny, Verdurmen, Wouter P.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362089/
https://www.ncbi.nlm.nih.gov/pubmed/37485031
http://dx.doi.org/10.1016/j.omto.2023.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362089/
https://www.ncbi.nlm.nih.gov/pubmed/37485031
http://dx.doi.org/10.1016/j.omto.2023.06.002

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