Cargando…
Potent and selective eradication of tumor cells by an EpCAM-targeted Ras-degrading enzyme
Despite decades of efforts, an urgent need remains to develop tumor cell-selective rat sarcoma (Ras)-targeting therapies that can treat patients with Ras-driven tumors. Here we report modular engineered proteins that degrade Ras selectively in tumor cells that overexpress the tumor cell marker epith...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362089/ https://www.ncbi.nlm.nih.gov/pubmed/37485031 http://dx.doi.org/10.1016/j.omto.2023.06.002 |