Ru(phen)(3)Cl(2)‐Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes

A novel Ru(phen)(3)Cl(2)‐catalyzed free‐radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8‐aminoquinoline‐derived inert enamides were reacted with the Togni regent to afford a broad range of Cl‐containing trifluoromethyl derivatives in good yields. The...

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Detalles Bibliográficos
Autores principales: Su, Wenhao, Cui, Jing, Zeng, Runsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362121/
https://www.ncbi.nlm.nih.gov/pubmed/37480185
http://dx.doi.org/10.1002/open.202300068
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author Su, Wenhao
Cui, Jing
Zeng, Runsheng
author_facet Su, Wenhao
Cui, Jing
Zeng, Runsheng
author_sort Su, Wenhao
collection PubMed
description A novel Ru(phen)(3)Cl(2)‐catalyzed free‐radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8‐aminoquinoline‐derived inert enamides were reacted with the Togni regent to afford a broad range of Cl‐containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl.
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spelling pubmed-103621212023-07-23 Ru(phen)(3)Cl(2)‐Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes Su, Wenhao Cui, Jing Zeng, Runsheng ChemistryOpen Research Articles A novel Ru(phen)(3)Cl(2)‐catalyzed free‐radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8‐aminoquinoline‐derived inert enamides were reacted with the Togni regent to afford a broad range of Cl‐containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl. John Wiley and Sons Inc. 2023-07-21 /pmc/articles/PMC10362121/ /pubmed/37480185 http://dx.doi.org/10.1002/open.202300068 Text en © 2023 The Authors. ChemistryOpen published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Su, Wenhao
Cui, Jing
Zeng, Runsheng
Ru(phen)(3)Cl(2)‐Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes
title Ru(phen)(3)Cl(2)‐Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes
title_full Ru(phen)(3)Cl(2)‐Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes
title_fullStr Ru(phen)(3)Cl(2)‐Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes
title_full_unstemmed Ru(phen)(3)Cl(2)‐Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes
title_short Ru(phen)(3)Cl(2)‐Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes
title_sort ru(phen)(3)cl(2)‐catalyzed chlorotrifluoromethylation of unactivated alkenes
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362121/
https://www.ncbi.nlm.nih.gov/pubmed/37480185
http://dx.doi.org/10.1002/open.202300068
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