Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) commonly targeted for inhibition by anticancer therapeutics. Current therapeutics target EGFR’s kinase domain or extracellular region. However, these types of inhibitors are not specific for tumors over healthy tissue an...

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Detalles Bibliográficos
Autores principales: Rybak, Jennifer A., Sahoo, Amita R., Kim, Soyeon, Pyron, Robert J., Pitts, Savannah B., Guleryuz, Saffet, Smith, Adam W., Buck, Matthias, Barrera, Francisco N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Membrane Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362150/
https://www.ncbi.nlm.nih.gov/pubmed/37315787
http://dx.doi.org/10.1016/j.jbc.2023.104914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362150/
https://www.ncbi.nlm.nih.gov/pubmed/37315787
http://dx.doi.org/10.1016/j.jbc.2023.104914

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