Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists

Toll-like receptor (TLR) agonists are recognized as potential immune-enhancing adjuvants and are included in several licensed vaccines. Monophosphoryl lipid A (MPL®, GlaxoSmithKline) is one such TLR4 agonist that has been approved for use in human vaccines, such as Cervarix and Shingrix. Due to the...

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Detalles Bibliográficos
Autores principales: Hu, Gang, Varisco, David J., Das, Sayan, Middaugh, C. Russell, Gardner, Francesca, Ernst, Robert K., Picking, Wendy L., Picking, William D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362264/
https://www.ncbi.nlm.nih.gov/pubmed/37483830
http://dx.doi.org/10.1016/j.heliyon.2023.e18119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362264/
https://www.ncbi.nlm.nih.gov/pubmed/37483830
http://dx.doi.org/10.1016/j.heliyon.2023.e18119

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