Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs

Retrotrapezoid nucleus (RTN) neurons in the brainstem regulate the ventilatory response to hypercarbia. It is unclear how PHOX2B-polyalanine repeat mutations (PHOX2B-PARMs) alter the function of PHOX2B and perturb the formation of RTN neurons. Here, we generated human brainstem organoids (HBSOs) wit...

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Detalles Bibliográficos
Autores principales: Lui, Kathy Nga-Chu, Li, Zhixin, Lai, Frank Pui-Ling, Lau, Sin-Ting, Ngan, Elly Sau-Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362500/
https://www.ncbi.nlm.nih.gov/pubmed/37352849
http://dx.doi.org/10.1016/j.stemcr.2023.05.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362500/
https://www.ncbi.nlm.nih.gov/pubmed/37352849
http://dx.doi.org/10.1016/j.stemcr.2023.05.020

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