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Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs
Retrotrapezoid nucleus (RTN) neurons in the brainstem regulate the ventilatory response to hypercarbia. It is unclear how PHOX2B-polyalanine repeat mutations (PHOX2B-PARMs) alter the function of PHOX2B and perturb the formation of RTN neurons. Here, we generated human brainstem organoids (HBSOs) wit...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362500/ https://www.ncbi.nlm.nih.gov/pubmed/37352849 http://dx.doi.org/10.1016/j.stemcr.2023.05.020 |