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GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling

BACKGROUND: The production of human chorionic gonadotropin (hCG) by the placental trophoblast cells is essential for maintaining a normal pregnancy. Aberrant hCG levels are associated with reproductive disorders. The protein of hCG is a dimer consisting of an α subunit and a β subunit. The β subunit...

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Detalles Bibliográficos
Autores principales: Wu, Ze, Zhang, Lingling, Jia, Yuanyuan, Bi, Beibei, Fang, Lanlan, Cheng, Jung-Chien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362589/
https://www.ncbi.nlm.nih.gov/pubmed/37480123
http://dx.doi.org/10.1186/s12964-023-01201-5