KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway

BACKGROUND: Studies reported that kelch-like protein 3 (KLHL3)-Cullin3(CUL3) E3 ligase ubiquitinated with-no-lysine kinase 4 (WNK4). Impaired WNK4 ubiquitination plays a key role in Familial hyperkalemic hypertension (FHHt, also called pseudohypoaldosteronism type II) which results from overaction o...

Descripción completa

Detalles Bibliográficos
Autores principales: Ying, Siqi, Guo, Qin, Zhang, Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362690/
https://www.ncbi.nlm.nih.gov/pubmed/37481568
http://dx.doi.org/10.1186/s12882-023-03257-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362690/
https://www.ncbi.nlm.nih.gov/pubmed/37481568
http://dx.doi.org/10.1186/s12882-023-03257-4

Ejemplares similares