Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis

Post-translational modifications to the carboxyl (C) terminus domain of α-synuclein can play an important role in promoting the pathologic aggregation of α-synuclein. Various cleavages that diminish this highly charged, proline-rich region can result in exposure of hydrophobic, aggregation-prone reg...

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Detalles Bibliográficos
Autores principales: Lloyd, Grace M., Long, Brooke, Quintin, Stephan, Sorrentino, Zachary A., Gorion, Kimberly-Marie M., Bell, Brach M., Carrillo, Denise, Sullivan, Patrick, Borchelt, David, Giasson, Benoit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363304/
https://www.ncbi.nlm.nih.gov/pubmed/37482615
http://dx.doi.org/10.1186/s40478-023-01623-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363304/
https://www.ncbi.nlm.nih.gov/pubmed/37482615
http://dx.doi.org/10.1186/s40478-023-01623-9

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