Cargando…

Fabrication and Evaluation of a pH-Responsive Nanocomposite-Based Colonic Delivery System for Improving the Oral Efficacy of Liraglutide

PURPOSE: Oral administration of liraglutide, a protein drug, suffers from low intestinal absorption and instability in the gastrointestinal tract, resulting in low bioavailability. The present study aimed to develop a pH-responsive nanocomposite based-colonic delivery system to improve the oral effi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Jae Geun, Kim, Da Hyun, Han, Hyo-Kyung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363350/ https://www.ncbi.nlm.nih.gov/pubmed/37489139 http://dx.doi.org/10.2147/IJN.S413515

Ejemplares similares

Enhanced oral delivery of insulin via the colon-targeted nanocomposite system of organoclay/glycol chitosan/Eudragit(®)S100
por: Lee, Sang Hoon, et al.
Publicado: (2020)

Site-selective oral delivery of therapeutic antibodies to the inflamed colon via a folic acid-grafted organic/inorganic hybrid nanocomposite system
por: Lee, Sang Hoon, et al.
Publicado: (2022)

Development of an M cell targeted nanocomposite system for effective oral protein delivery: preparation, in vitro and in vivo characterization
por: Song, Jae Geun, et al.
Publicado: (2021)

Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery
por: Barea, M. J., et al.
Publicado: (2012)

pH-Sensitive Mebeverine Microspheres for Colon Delivery
por: Dandagi, P. M., et al.
Publicado: (2009)

Fabrication of pH-dependent solid dispersion for oral colon-targeted delivery of notoginsenoside R1 and its protective effects on ulcerative colitis mice()
por: Tie, Hongyun, et al.
Publicado: (2023)

Smart Microparticles with a pH-responsive Macropore for Targeted Oral Drug Delivery
por: Kumar, Ankit, et al.
Publicado: (2017)

pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia
por: Keshavarz, Hasan, et al.
Publicado: (2020)

Ternary nanocomposite carriers based on organic clay-lipid vesicles as an effective colon-targeted drug delivery system: preparation and in vitro/in vivo characterization
por: Kim, Hyeon Young, et al.
Publicado: (2020)

Nanocomposites-based targeted oral drug delivery systems with infliximab in a murine colitis model
por: Kim, Jung Min, et al.
Publicado: (2020)

pH-Responsive Nanocomposite Based Hydrogels for the Controlled Delivery of Ticagrelor; In Vitro and In Vivo Approaches
por: Shahid, Nariman, et al.
Publicado: (2021)

pH-sensitive Au–BSA–DOX–FA nanocomposites for combined CT imaging and targeted drug delivery
por: Huang, He, et al.
Publicado: (2017)

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon
por: Ashwanikumar, N, et al.
Publicado: (2012)

Daunorubicin-TiO(2) nanocomposites as a “smart” pH-responsive drug delivery system
por: Zhang, Haijun, et al.
Publicado: (2012)

Fabrication of pH-responsive PLGA(UCNPs/DOX) nanocapsules with upconversion luminescence for drug delivery
por: Zhao, Junwei, et al.
Publicado: (2017)

Intestinal epithelium penetration of liraglutide via cholic acid pre-complexation and zein/rhamnolipids nanocomposite delivery
por: Bao, Xiaoyan, et al.
Publicado: (2023)

Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite
por: Mahkam, Mehrdad, et al.
Publicado: (2010)

A novel pH–enzyme-dependent mesalamine colon-specific delivery system
por: Jin, Lei, et al.
Publicado: (2016)

Fabrication and Intracellular Delivery of Doxorubicin/Carbonate Apatite Nanocomposites: Effect on Growth Retardation of Established Colon Tumor
por: Hossain, Sharif, et al.
Publicado: (2013)

One-Step Fabrication of Hollow Spherical Cellulose Beads: Application in pH-Responsive Therapeutic Delivery
por: Mohan, Tamilselvan, et al.
Publicado: (2022)

Microfluidic-Assisted Fabrication of Dual-Coated pH-Sensitive Mesoporous Silica Nanoparticles for Protein Delivery
por: Küçüktürkmen, Berrin, et al.
Publicado: (2022)

Facile fabrication of microparticles with pH-responsive macropores for small intestine targeted drug formulation
por: Homayun, Bahman, et al.
Publicado: (2018)

Aspirin is associated with low oral pH levels and antacid helps to increase oral pH
por: Ediriweera, Dileepa Senajith, et al.
Publicado: (2018)

Designing of pH-Sensitive Hydrogels for Colon Targeted Drug Delivery; Characterization and In Vitro Evaluation
por: Suhail, Muhammad, et al.
Publicado: (2022)

Application of pH-Responsive Fucoidan/Chitosan Nanoparticles to Improve Oral Quercetin Delivery
por: Barbosa, Ana Isabel, et al.
Publicado: (2019)

Mesoscale Simulations of pH-Responsive Amphiphilic Polymeric Micelles for Oral Drug Delivery
por: Wu, Zhimin, et al.
Publicado: (2019)

pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms
por: Liu, Lin, et al.
Publicado: (2017)

Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen
por: Li, Chen, et al.
Publicado: (2021)

Fabrication of fluorescent pH-responsive protein–textile composites
por: Saldanha, Dalia Jane, et al.
Publicado: (2020)

pH-Sensitive Biomaterials for Drug Delivery
por: Zhuo, Shijie, et al.
Publicado: (2020)

Fabrication of baicalein‐encapsulated zeolitic imidazole framework as a novel nanocomposited wound closure material to persuade pH‐responsive healing efficacy in post‐caesarean section wound care
por: Yang, Jing, et al.
Publicado: (2022)

One-pot hydrothermal synthesis of a magnetic hydroxyapatite nanocomposite for MR imaging and pH-Sensitive drug delivery applications
por: Kermanian, Mehraneh, et al.
Publicado: (2020)

Construction of pH-responsive and up-conversion luminescent NaYF(4):Yb(3+)/Er(3+)@SiO(2)@PMAA nanocomposite for colon targeted drug delivery
por: Tian, Boshi, et al.
Publicado: (2016)

Fabrication Of Dual pH/redox-Responsive Lipid-Polymer Hybrid Nanoparticles For Anticancer Drug Delivery And Controlled Release
por: Men, Wanfu, et al.
Publicado: (2019)

pH-sensitive dual drug loaded janus nanoparticles by oral delivery for multimodal analgesia
por: Liu, Lin, et al.
Publicado: (2021)

pH-Responsive Cellulose-Based Microspheres Designed as an Effective Oral Delivery System for Insulin
por: Gong, Yaqi, et al.
Publicado: (2021)

Preparation of pH-Responsive Hydrogels Based on Chondroitin Sulfate/Alginate for Oral Drug Delivery
por: Suhail, Muhammad, et al.
Publicado: (2022)

Rapid Colorimetric pH-Responsive Gold Nanocomposite Hydrogels for Sensing Applications
por: Salih, Ahmed E., et al.
Publicado: (2022)

Encapsulation of Curcumin-Loaded Liposomes for Colonic Drug Delivery in a pH-Responsive Polymer Cluster Using a pH-Driven and Organic Solvent-Free Process
por: De Leo, Vincenzo, et al.
Publicado: (2018)

Novel Black Seed Polysaccharide Extract-g-Poly (Acrylate) pH-Responsive Hydrogel Nanocomposites for Safe Oral Insulin Delivery: Development, In Vitro, In Vivo and Toxicological Evaluation
por: Shabir, Farya, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ooh47vcq4p924c9ktmoth6sn2o