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AAV-CRISPR-Cas13 eliminates human enterovirus and prevents death of infected mice
BACKGROUND: RNA viruses account for many human diseases and pandemic events but are often not targetable by traditional therapeutics modalities. Here, we demonstrate that adeno-associated virus (AAV) -delivered CRISPR-Cas13 directly targets and eliminates the positive-strand EV-A71 RNA virus in cell...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363442/ https://www.ncbi.nlm.nih.gov/pubmed/37390772 http://dx.doi.org/10.1016/j.ebiom.2023.104682 |