AAV-CRISPR-Cas13 eliminates human enterovirus and prevents death of infected mice

BACKGROUND: RNA viruses account for many human diseases and pandemic events but are often not targetable by traditional therapeutics modalities. Here, we demonstrate that adeno-associated virus (AAV) -delivered CRISPR-Cas13 directly targets and eliminates the positive-strand EV-A71 RNA virus in cell...

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Detalles Bibliográficos
Autores principales: Keng, Choong Tat, Yogarajah, Thinesshwary, Lee, Regina Ching Hua, Muhammad, Irfan Bin Hajis, Chia, Bing Shao, Vasandani, Suraj Rajan, Lim, Daryl Shern, Guo, Ke, Wong, Yi Hao, Mok, Chee Keng, Chu, Justin Jang Hann, Chew, Wei Leong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363442/
https://www.ncbi.nlm.nih.gov/pubmed/37390772
http://dx.doi.org/10.1016/j.ebiom.2023.104682

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