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Apolipoprotein E is required for brain iron homeostasis in mice
BACKGROUND: Apolipoprotein E deficiency (ApoE(−/−)) increases progressively iron in the liver, spleen and aortic tissues with age in mice. However, it is unknown whether ApoE affects brain iron. METHODS: We investigated iron contents, expression of transferrin receptor 1 (TfR1), ferroportin 1 (Fpn1)...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363452/ https://www.ncbi.nlm.nih.gov/pubmed/37339558 http://dx.doi.org/10.1016/j.redox.2023.102779 |